Protein

Protein accession
A0A345AQF2 [UniProt]
Representative
4CbZx
Source
UniProt (cluster: phalp2_35819)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MVSKVQFNPRSRTDAIFVHCSATKPEMDIGVETIRMWHKQQGWLDVGYHFIIKRDGTVEEGRPVNVVGSHVKDWNSRSVGVCLVGGIDAKGKFEANFTPDQMNSLRNKLADLKSLYPQAEIKAHHDVAPKACPSFDLQRWLSTNELVTSDHG
Physico‐chemical
properties
protein length:152 AA
molecular weight:17073,2 Da
isoelectric point:7,79
hydropathy:-0,45
Representative Protein Details
Accession
4CbZx
Protein name
4CbZx
Sequence length
239 AA
Molecular weight
26094,43340 Da
Isoelectric point
8,96615
Sequence
MRRRSTDHLVLHCSATPPTADIGAAEIRQWHKAKGWNDIGYHLVIRRNGEVEEGRSLEEIGSHVRNHNASSVGICLVGGVDARQRPRNNFTTAQWNSLKDRLAGLQSRFPASRVIGHRDFPGVAKACPCFDAIDWAEANGFRVAARLQPVTSSMLRAVRREMEDGDEVDDVASVPITGPGKWLAAILGSGGAGSLAGFGYGMDWVSLLVLILGLASMTCGVLLAIGRERRERLWDRLFG
Other Proteins in cluster: phalp2_35819
Total (incl. this protein): 312 Avg length: 154,6 Avg pI: 8,59
Protein ID Length (AA) pI
4CbZx 239 8,96615
11JEy 262 6,65360
11JuK 245 8,92747
3e2WQ 195 9,50059
4Cc6G 253 8,70550
4QdnV 204 9,09696
6g1vR 155 9,30068
7vGJF 239 9,07426
7vxTI 254 7,03504
7ynoV 254 8,22605
OW8K 239 8,94700
A0A7G9UTD9 151 8,80814
A0A5P1KKN4 151 8,46736
A0A3S7N8P7 152 9,05138
Q859G4 146 9,43625
A0A1Z1LW00 152 8,45459
A0A384WIG2 152 8,82561
A0A2D3QLT6 152 8,44234
A0A2U8USP6 151 8,46736
A0A1L7DRY8 149 9,37501
A0A1V0E671 151 8,80814
A0A1S6KVG4 153 8,48077
A0A2Z4QJC6 153 9,07330
L7TML5 203 9,37933
A0A3G1L2Y1 151 8,44544
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_5171
285Oe
 13 51,8% 162 1.120E-61
2 phalp2_25557
3CTPR
 25 37,0% 240 4.317E-50
3 phalp2_9794
8qYns
 5 42,2% 154 4.751E-48
4 phalp2_28171
8yYQh
 287 39,6% 169 3.413E-45
5 phalp2_25618
48uUY
 31 36,6% 183 3.538E-32
6 phalp2_2920
NQqI
 114 33,7% 169 3.745E-30
7 phalp2_14613
5sQyS
 2 30,5% 154 5.108E-30
8 phalp2_30941
13o5z
 7 30,8% 149 4.209E-24
9 phalp2_18287
4ZlaN
 11 31,7% 164 3.150E-20
10 phalp2_20811
63TES
 2 28,4% 172 2.092E-11

Domains

Domains [InterPro]
Ami2
Unannotated
Disordered region
Representative sequence (used for alignment): 4CbZx (239 AA)
Member sequence: A0A345AQF2 (152 AA)
1 239 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Escherichia phage Vec13
[NCBI] 		2783859 Autographiviridae > Kayfunavirus > Kayfunavirus Vec13
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH400309 [NCBI]
CDS location
range 10508 -> 10966
strand +
CDS
ATGGTAAGTAAGGTACAGTTCAACCCACGGTCCCGGACTGACGCTATCTTCGTTCACTGTTCGGCTACCAAGCCAGAGATGGACATCGGGGTAGAGACCATCCGTATGTGGCACAAGCAGCAAGGCTGGCTGGACGTAGGCTACCACTTTATCATCAAGCGCGATGGTACTGTGGAAGAGGGTCGCCCGGTAAACGTCGTAGGGTCACACGTTAAGGACTGGAACTCACGGTCTGTAGGCGTCTGCCTTGTAGGTGGAATCGACGCTAAGGGCAAGTTTGAAGCTAACTTCACTCCGGACCAGATGAACTCCCTACGCAACAAGCTGGCTGACCTGAAGTCCCTGTATCCTCAGGCAGAAATCAAAGCACATCATGATGTAGCACCAAAGGCGTGTCCAAGTTTCGACTTACAGCGCTGGCTGTCTACTAATGAGCTGGTCACTTCCGACCACGGTTAA

Gene Ontology

Description Category Evidence (source)
GO:0008270 zinc ion binding molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0032897 negative regulation of viral transcription biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		HAMAP-Rule:MF_04111

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4CbZx) rather than this protein.
PDB ID
4CbZx
Method AlphaFoldv2
Resolution 79.53
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50