Protein

Protein accession
A0A0C5PVL1 [UniProt]
Representative
5HBET
Source
UniProt (cluster: phalp2_9110)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MSLRTKVIATLTGATMLGGAITGVVQHNEGLSLTAYKDSAGVPTICYGETKGVKMGQRATLSDCQKQLIQSAGEHAKALDGLPMQLSDVALVGSIDFIYNVGVAGFNGSAVKRHLKNLDYAAAGRAVLDWRYISKYQQKSPGTGWVYKGSNRWTFDCSQYINGQRNKVCWGLWERRQWQSKAIGNQYKNVNAAVSALIKSGG
Physico‐chemical
properties
protein length:202 AA
molecular weight:21895,7 Da
isoelectric point:9,67
hydropathy:-0,25
Representative Protein Details
Accession
5HBET
Protein name
5HBET
Sequence length
104 AA
Molecular weight
11308,02950 Da
Isoelectric point
6,55691
Sequence
MASRLAKNTILAGVLVSLVGGFEGLRTVAYLDPVGIPTVCFGETKGVKLGDRYTKEECKDMLKESLVEHERGMRKCLGRPDDIPDLTYGAFLSFTYNVGVGAFC
Other Proteins in cluster: phalp2_9110
Total (incl. this protein): 95 Avg length: 191,3 Avg pI: 9,45
Protein ID Length (AA) pI
5HBET 104 6,55691
3gBom 98 4,24493
4Ts8O 96 6,05662
6VBCT 88 5,67022
7nLDe 118 9,58118
8bkPr 117 8,95023
8tQhn 111 9,69342
eXCD 131 9,14673
A0A1D8ES60 202 9,59504
A0A2S1ZES1 199 9,64823
Q3HQU9 165 9,14853
A0A0P0HS42 184 9,64855
A0A1B0Z137 202 9,78793
A0A142F120 202 9,78793
A0A068Q6B6 202 9,64855
A0A0S2MXR6 202 9,61780
D1L301 202 9,71940
V9QL51 199 9,67131
A0A482II55 199 9,58092
A0A1U8V571 188 9,64197
A0A0C5Q3S9 202 9,69645
A0A2P0XN13 203 9,24536
A0A1I9SEI7 199 9,69645
A0A5B9NC12 202 9,57383
A0A5B9NC51 202 9,57383
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4305
8aoFg
 2477 52,5% 99 9.684E-36
2 phalp2_11002
4Mz75
 307 44,6% 94 2.338E-27
3 phalp2_2632
6RhYr
 14867 41,0% 100 2.611E-21
4 phalp2_35864
4Lj4w
 95 40,0% 115 1.165E-19
5 phalp2_25155
1IVIw
 4 34,0% 100 3.471E-17
6 phalp2_37312
8djZH
 4 43,0% 86 1.231E-16
7 phalp2_26644
2b0IA
 24 38,7% 80 8.219E-16
8 phalp2_21089
jcH9
 1 36,0% 86 1.128E-15
9 phalp2_31530
48EM7
 20 36,2% 91 2.914E-15
10 phalp2_17749
7tNIh
 28 32,0% 75 5.025E-14

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 5HBET (104 AA)
Member sequence: A0A0C5PVL1 (202 AA)
1 104 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Klebsiella phage vB_KpnP_SU552A
[NCBI] 		1610835 Autographiviridae > Drulisvirus > Drulisvirus SU552A
Host Klebsiella pneumoniae
[NCBI] 		573 Proteobacteria > Gammaproteobacteria > Enterobacteriales > Enterobacteriaceae > Klebsiella >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KP708986 [NCBI]
CDS location
range 41192 -> 41800
strand +
CDS
ATGAGTTTAAGGACTAAGGTTATTGCGACCCTCACGGGGGCCACTATGCTCGGCGGTGCCATTACCGGCGTAGTCCAGCACAACGAGGGCCTGAGCCTTACCGCCTACAAGGATAGCGCCGGTGTCCCTACAATCTGCTACGGGGAGACAAAGGGCGTTAAAATGGGCCAGAGAGCCACGCTGAGCGATTGTCAGAAGCAACTGATACAATCAGCAGGGGAACACGCAAAAGCTCTTGACGGGCTTCCTATGCAGCTCTCTGACGTAGCCCTGGTTGGGTCTATAGACTTCATTTATAACGTAGGCGTAGCGGGCTTCAACGGTAGTGCCGTGAAGCGGCATCTCAAGAATCTAGATTACGCCGCGGCCGGAAGGGCTGTACTGGACTGGCGCTATATTAGCAAGTACCAGCAGAAGTCCCCCGGCACCGGCTGGGTGTACAAGGGCAGCAACCGCTGGACCTTCGACTGCTCTCAGTACATTAATGGGCAGCGCAATAAAGTGTGCTGGGGCCTATGGGAGCGCAGGCAGTGGCAGAGCAAAGCCATTGGGAACCAGTATAAGAATGTAAATGCGGCGGTGTCCGCCCTAATTAAATCTGGAGGATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

PDB ID
upi0005d7efc5_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (5HBET) rather than this protein.
PDB ID
5HBET
Method AlphaFoldv2
Resolution 95.01
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50