Protein

Protein accession
A0A077KCE6 [UniProt]
Representative
7zmZV
Source
UniProt (cluster: phalp2_28113)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTPSEKCLKLIREFEGCRLEAYKCPAGKLTIGYGWTRPVDGVPIHAGMKITKETAERLLKVGADEYGREVSSALRVSVSQSQFDALVSFAYNFGLPVLSGSTLLRKLNAGDYAGAAAEFPRWNKSKGKPLPGLTRRREAERCLFLS
Physico‐chemical
properties
protein length:146 AA
molecular weight:16070,4 Da
isoelectric point:9,51
hydropathy:-0,26
Representative Protein Details
Accession
7zmZV
Protein name
7zmZV
Sequence length
225 AA
Molecular weight
24737,53110 Da
Isoelectric point
9,77620
Sequence
MKISQTGINLIKQFEGCYLTAYKCPAGVWTIGYGTTGKVDGKQICSGMKINKQKAEQLLKKDLEQFEKAVSAIVKVPINQNQFDALVSFSYNCGSSALRKSTLLRKLNQKDYKGAAEEFLKWNKAGGKVLAGLARRREAERKLFLASSGAKEPSKTHKTTYLTVTANSGLLCRKTASINGQVLGTFTKGTKVELLDGNKEIWYKVKGKCVAGKVIVGYCSSRYLE
Other Proteins in cluster: phalp2_28113
Total (incl. this protein): 50 Avg length: 189,8 Avg pI: 8,75
Protein ID Length (AA) pI
7zmZV 225 9,77620
1Xp50 165 9,89707
1daa8 251 9,26825
1uijz 162 6,92193
1z2D6 162 5,30617
21CWq 227 9,75653
24n4b 227 9,93408
25CM6 165 10,23083
4HUcu 212 5,08649
4MnAK 203 10,41353
67zC7 205 9,69677
6H5rO 218 5,00549
6x5rw 222 8,94359
7Vu2f 209 9,21816
7sBg8 254 9,51175
7vMog 254 9,68523
A0A0M4S5S1 146 7,69557
A0A1B1P9G1 149 9,70986
A0A0M4R365 149 9,01289
A0A7D2HHD8 146 9,21107
A0A3G3BZ23 146 8,71730
A0A068CDE9 184 9,25458
A0A4D6CHH5 137 9,46017
A0A075DXC6 206 8,71524
A0A0B5KND4 146 9,51871
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_2632
6RhYr
 14867 61,6% 146 7.498E-70
2 phalp2_33221
5jbqV
 447 63,5% 148 1.407E-69
3 phalp2_6830
8n5Jv
 121 59,0% 149 3.616E-69
4 phalp2_2498
5GMvl
 297 61,6% 159 2.389E-68
5 phalp2_10966
4MkR6
 70 52,2% 155 2.679E-66
6 phalp2_29738
1pBjt
 830 55,4% 166 1.291E-65
7 phalp2_4451
31DIk
 4919 61,4% 148 2.423E-65
8 phalp2_2176
3Yhf4
 930 57,5% 158 3.033E-61
9 phalp2_126
5jCCA
 637 55,1% 147 1.320E-59
10 phalp2_4532
3QBcV
 9 61,5% 143 4.640E-59

Domains

Domains [InterPro]
GH24
SH3_3
Representative sequence (used for alignment): 7zmZV (225 AA)
Member sequence: A0A077KCE6 (146 AA)
1 225 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Edwardsiella phage GF-2
[NCBI] 		1537091 Gofduovirus > Gofduovirus GF2
Host Edwardsiella tarda
[NCBI] 		636 Proteobacteria > Gammaproteobacteria > Enterobacteriales > Enterobacteriaceae > Edwardsiella >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
AP014629 [NCBI]
CDS location
range 40746 -> 41186
strand +
CDS
ATGACGCCAAGCGAGAAGTGTCTGAAGCTGATCCGAGAGTTTGAGGGTTGCCGACTTGAGGCTTACAAGTGCCCGGCTGGCAAGTTGACAATCGGCTATGGATGGACGCGGCCAGTTGATGGAGTGCCGATTCATGCCGGTATGAAGATCACCAAAGAAACAGCTGAACGCCTTCTTAAGGTTGGCGCGGATGAATATGGACGAGAAGTTTCATCCGCGCTGAGGGTTTCCGTTTCTCAGAGTCAATTTGATGCGCTGGTTAGCTTTGCTTATAACTTTGGCCTTCCCGTCTTATCCGGATCAACTCTGCTGCGCAAGCTGAATGCCGGTGATTATGCCGGTGCCGCTGCTGAATTCCCCCGCTGGAACAAGAGCAAAGGAAAACCGCTCCCAGGGTTAACGCGTCGCCGGGAGGCTGAGCGATGCCTTTTCTTATCCTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
A0A077KCE6
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7zmZV) rather than this protein.
PDB ID
7zmZV
Method AlphaFoldv2
Resolution 92.54
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50