Protein

Protein accession
A0A291AXT8 [UniProt]
Representative
1pDJr
Source
UniProt (cluster: phalp2_20036)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MQLSSKGLEAIKFFEGLRLEAYKDSAGIPTIGYGTIRINGRPVTMGMKITAEQAEQYLLADVENYVGAVNRAIKVPTTQNEFDALVVETYNIGIGAMQDSTFIKRHNAGNKAGCAEAMQWWNKITVNGQKVTSKGLQNRRSLEAKIYLDAVYPK
Physico‐chemical
properties
protein length:154 AA
molecular weight:17021,0 Da
isoelectric point:9,16
hydropathy:-0,30
Representative Protein Details
Accession
1pDJr
Protein name
1pDJr
Sequence length
408 AA
Molecular weight
43416,77080 Da
Isoelectric point
5,01550
Sequence
MRISPEGLTLIKRFEGLRLHAYQDVGGVWTIGYGTTRTPDGPVAEGQRITQTEAEAFLADDVREFEQGVDAAVTVGVTQPMFDALVSLAYNVGLGAFRGSTLLRKLNARDWEGAAAEFARWNKVGQTVVDGLTRRRAEEAAVFRAGVAQLTMQPAGPAPAAQPTASAPVAEAPAPAAPAPPPPYIDPMRSPEEARADEAWVRIERERLEAASIAATDTPGGPTMPLPVSAVVALGGELLKLLPFAAKPQQQDKLDTLAQQLVRIAQAVQPASVNEQQAVEQVRANPQLQRAFVAEAASQWSELQPLLEFEAGEREKARGFVEALTSGDAPMWRQIGAAGIVGVLSLLLIGGGGWIFYTMLIGDALDAGQKGMVLGALLAAFSGAVSFWFGSSASSQRKDRTIEEQARK
Other Proteins in cluster: phalp2_20036
Total (incl. this protein): 122 Avg length: 156,1 Avg pI: 9,18
Protein ID Length (AA) pI
1pDJr 408 5,01550
A0A384TAV0 154 8,88698
A0A6B9WWR1 154 8,57205
D2K0A1 154 9,07787
A0A1B1PD64 154 9,07787
A0A291AYS9 154 9,13893
A0A0K2CN83 154 9,27682
A0A0E3XCC0 154 9,23395
A0A142EZW8 159 9,40763
A0A2I6PH21 154 9,23395
K4I0N0 154 9,44721
A0A2I6PHR1 154 9,23395
A0A653FXZ4 154 9,36095
A0A7G3M9T8 154 8,92476
A0A0D4DAU1 154 9,23395
A0A0B5HA99 154 9,23395
A0A0K1LPG6 154 9,13867
A0A2K9V2F8 154 9,30010
K9K9S8 154 9,09715
A0A1V0DYV1 154 9,40673
A0A0N9SI93 154 9,36095
A0A0A0RKF2 154 9,25484
A0A0F6R666 154 8,88698
A0A0F6R9G3 154 8,88698
A0A0H3UCP7 154 9,23395
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37963
5hjd8
 62 38,4% 416 2.095E-60
2 phalp2_37960
5fckM
 10 34,0% 411 1.023E-43

Domains

Domains [InterPro]
GH24
Unannotated
Unannotated
Representative sequence (used for alignment): 1pDJr (408 AA)
Member sequence: A0A291AXT8 (154 AA)
1 408 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Shigella phage Sf13
[NCBI] 		2024316 Mooglevirus > Mooglevirus Sf13
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MF158040 [NCBI]
CDS location
range 20880 -> 21344
strand +
CDS
ATGCAACTCTCAAGTAAAGGCTTAGAAGCCATTAAGTTCTTTGAAGGGCTTCGTTTAGAAGCCTATAAAGACTCTGCTGGAATCCCTACAATTGGTTATGGTACAATTCGTATCAACGGAAGACCTGTTACGATGGGGATGAAGATTACTGCCGAGCAAGCTGAACAATATCTCCTTGCAGATGTTGAGAACTATGTAGGTGCAGTAAACAGAGCAATTAAGGTTCCAACTACGCAGAACGAATTTGACGCACTTGTTGTAGAGACTTACAACATTGGCATCGGTGCTATGCAGGATTCAACTTTTATCAAGCGTCACAATGCTGGTAACAAAGCTGGTTGTGCAGAAGCTATGCAGTGGTGGAACAAGATTACAGTGAATGGTCAAAAAGTAACTTCCAAGGGTCTACAAAATAGACGTAGTTTGGAAGCCAAGATTTACCTTGACGCTGTTTATCCAAAATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi000bc0d212_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (1pDJr) rather than this protein.
PDB ID
1pDJr
Method AlphaFoldv2
Resolution 71.43
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50