Protein

Protein accession
A0A7G3RZW8 [UniProt]
Representative
4e1Vs
Source
UniProt (cluster: phalp2_31548)
Protein name
Holin family protein
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MQIEKPKLAFKGKLTPIKKVTKVVCHHPAHPTWGIMEIHNYHKNSKGWAGIGYNYLICKDGRIQEGRGKNVGAHCSGRNSDTLGVCFQGDFDKQQMTDAQVKAGGWLIAKLIKEHGLQINDVLGHRDLAATACPGKNFRMADLKAEILANLNPKTKTPERKLSGMKPNWKDWQWKEAAEIYKKARVKGILSSDEWEKKAAAKNLTFDEIEYLNLVLNGRLL
Physico‐chemical
properties
protein length:221 AA
molecular weight:24872,6 Da
isoelectric point:9,56
hydropathy:-0,57
Representative Protein Details
Accession
4e1Vs
Protein name
4e1Vs
Sequence length
305 AA
Molecular weight
34011,41320 Da
Isoelectric point
9,23427
Sequence
MTIQKTNLKFSGTLSPIKKVTKIVVHHPAHPTWDIYEVHNYHKAKGWSGIGYNYFITKGGVQQEGRGKYVGAHCVGKNSYTLGVSFQGDFDKQELGDMQLKAGANLIAKLLREYGLQINDVVRHKDLAATDCPGKNFRFDDLKTAILHELNPNTIKPDVPKQQVESVSPKQEDLPKVTSLGDKYSFQVKAMQDTPVYEYANLSNRKNTLREGTVFSVYGYTYASWAVGGGGFVMMKHVDPVPVTLTTGGLNKGMEEEFRAFLKKEGIAAELNLNKTGNPSASITVQGLDLVKVRQFLDQKGWYYK
Other Proteins in cluster: phalp2_31548
Total (incl. this protein): 3 Avg length: 277,0 Avg pI: 9,34
Protein ID Length (AA) pI
4e1Vs 305 9,23427
79pHv 305 9,22422
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4457
35NNl
 1 33,6% 211 1.950E-24

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 4e1Vs (305 AA)
Member sequence: A0A7G3RZW8 (221 AA)
1 305 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacillus phage vB_Bacillus_1020A
[NCBI] 		2723960 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MT210152 [NCBI]
CDS location
range 23802 -> 24467
strand +
CDS
ATGCAAATAGAAAAGCCAAAACTGGCTTTTAAGGGCAAACTTACCCCTATAAAAAAAGTTACTAAGGTCGTCTGTCATCATCCTGCGCACCCAACGTGGGGCATTATGGAGATACACAATTATCACAAAAACTCTAAAGGATGGGCAGGCATAGGGTACAACTACTTAATTTGCAAAGATGGCCGTATCCAAGAGGGAAGAGGGAAAAATGTAGGTGCTCATTGCTCAGGACGTAATAGTGACACGCTAGGAGTTTGCTTTCAAGGGGATTTTGATAAGCAACAGATGACGGATGCACAGGTTAAGGCTGGCGGATGGTTGATCGCTAAACTAATCAAAGAGCATGGATTGCAGATTAATGATGTTCTTGGCCATCGTGATTTAGCTGCTACTGCTTGCCCTGGTAAAAACTTTAGGATGGCAGATTTAAAGGCTGAGATACTAGCAAATTTGAATCCTAAAACTAAAACACCTGAAAGGAAGTTGAGTGGAATGAAACCAAATTGGAAAGATTGGCAATGGAAAGAAGCTGCAGAGATTTATAAAAAAGCAAGGGTAAAAGGTATTTTATCCTCGGACGAGTGGGAGAAGAAAGCAGCAGCTAAGAATCTGACATTTGACGAAATTGAGTACCTTAACTTGGTGCTTAATGGTCGATTGTTGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008270 zinc ion binding molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
A0A7G3RZW8
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (4e1Vs) rather than this protein.
PDB ID
4e1Vs
Method AlphaFoldv2
Resolution 89.93
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50